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DESIGNING STATIONARY PHASES FOR IMPROVED PROTEIN SEPARATIONS

thesis
posted on 28.04.2022, 01:32 by Tyrel A WagnerTyrel A Wagner

  

As monoclonal antibodies (mAbs) become a more important part of the pharmaceutical industry, the need for better quicker analysis of then will also increase. To do this, better stationary phases specifically designed for mAbs need to be developed to analyze the quality of mAbs by their critical control attributes. The three main critical control attributes are size, charge, and glycosylation. This work focuses mainly on the development of stationary phases to analyze critical control attributes in size and charge through using a non-porous silica base and surface confined atom transfer radical polymerization to grow improved stationary phases that minimize undesired interactions and maximize desired interactions.

History

Degree Type

Doctor of Philosophy

Department

Chemistry

Campus location

West Lafayette

Advisor/Supervisor/Committee Chair

Mary J. Wirth

Additional Committee Member 2

Peter Kissinger

Additional Committee Member 3

Kavita Shah

Additional Committee Member 4

Scott McLuckey