Purdue University Graduate School
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DEVELOPMENT OF CARBONIC ANHYDRASE IX AND FOLATE TARGETED SMALL MOLECULE DRUG CONJUGATES FOR THE TREATMENT OF CANCER, SPINAL CORD INJURY AND INFLAMMATORY DISEASES

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thesis
posted on 2021-04-28, 22:43 authored by Spencer S GardeenSpencer S Gardeen
In the field of drug development, a major issue constantly preventing translation to the clinic is drug toxicity. With so many drugs failing phase 1 clinical trials for this reason, solutions need to be developed to overcome this obstacle. The content of this thesis includes three separate and distinct projects that utilized small molecule drug conjugate technology to maintain desired efficacy and circumvent the toxicities associated with the well-known drugs tubulysin B, hydralazine, and dexamethasone.

History

Degree Type

  • Doctor of Philosophy

Department

  • Chemistry

Campus location

  • West Lafayette

Advisor/Supervisor/Committee Chair

Philip S Low

Additional Committee Member 2

David Thompson

Additional Committee Member 3

Mingji Dai

Additional Committee Member 4

Chengde Mao