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DEVELOPMENT OF CARBONIC ANHYDRASE IX AND FOLATE TARGETED SMALL MOLECULE DRUG CONJUGATES FOR THE TREATMENT OF CANCER, SPINAL CORD INJURY AND INFLAMMATORY DISEASES

thesis
posted on 28.04.2021, 22:43 by Spencer S GardeenSpencer S Gardeen
In the field of drug development, a major issue constantly preventing translation to the clinic is drug toxicity. With so many drugs failing phase 1 clinical trials for this reason, solutions need to be developed to overcome this obstacle. The content of this thesis includes three separate and distinct projects that utilized small molecule drug conjugate technology to maintain desired efficacy and circumvent the toxicities associated with the well-known drugs tubulysin B, hydralazine, and dexamethasone.

History

Degree Type

Doctor of Philosophy

Department

Chemistry

Campus location

West Lafayette

Advisor/Supervisor/Committee Chair

Philip S Low

Additional Committee Member 2

David Thompson

Additional Committee Member 3

Mingji Dai

Additional Committee Member 4

Chengde Mao