DEVELOPMENT OF MASS SPECTROMETRIC METHODS FOR THE CHEMICAL CHARACTERIZATION OF CONDENSATE OILS, THE DETECTION OF REACTION INTERMEDIATES IN SOLUTION AND FOR THE FAST IDENTIFICATION OF DRUG METABOLITES
thesisposted on 2022-01-03, 01:10 authored by Kawthar Zeyad AlzarieniKawthar Zeyad Alzarieni
This dissertation presents several examples of diverse applications of mass spectrometry. For example, high-resolution mass spectrometry was utilized for qualitative and quantitative chemical characterization of ionized compounds in petrochemical samples, specifically, in condensate-like oil samples. Further, the ability to use tandem mass spectrometry to rapidly detect trace amounts of short-lived reaction intermediates in solution reactions is demonstrated. Finally, selective tandem mass spectrometry methods based on diagnostic gas-phase ion-molecule reactions were developed for the identification of carboxylic acid functionalities in protonated analytes.
- Doctor of Philosophy