2021.11.30 Thesis_Kawthar.pdf (6.05 MB)
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DEVELOPMENT OF MASS SPECTROMETRIC METHODS FOR THE CHEMICAL CHARACTERIZATION OF CONDENSATE OILS, THE DETECTION OF REACTION INTERMEDIATES IN SOLUTION AND FOR THE FAST IDENTIFICATION OF DRUG METABOLITES

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thesis
posted on 03.01.2022, 01:10 authored by Kawthar Zeyad AlzarieniKawthar Zeyad Alzarieni

This dissertation presents several examples of diverse applications of mass spectrometry. For example, high-resolution mass spectrometry was utilized for qualitative and quantitative chemical characterization of ionized compounds in petrochemical samples, specifically, in condensate-like oil samples. Further, the ability to use tandem mass spectrometry to rapidly detect trace amounts of short-lived reaction intermediates in solution reactions is demonstrated. Finally, selective tandem mass spectrometry methods based on diagnostic gas-phase ion-molecule reactions were developed for the identification of carboxylic acid functionalities in protonated analytes.

History

Degree Type

Doctor of Philosophy

Department

Chemistry

Campus location

Indianapolis

Advisor/Supervisor/Committee Chair

Hilkka I. Kenttamaa

Additional Committee Member 2

Julia Laskin

Additional Committee Member 3

Elizabeth Parkinson

Additional Committee Member 4

Gozdem Kilaz