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DISCOVERY AND BIOLOGICAL TESTING OF NOVEL ANTIBIOTICS

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DISCOVERY AND BIOLOGICAL TESTING OF NOVEL ANTIBIOTICS

thesis
posted on 2022-07-24, 18:49 authored by Whitney Marie GribbleWhitney Marie Gribble

The synthesis of novel oxadiazole antibiotics more water soluble than previously published analogues within the group will be discussed in this thesis as part of synthesizing a library with increased sp3 character.  These analogues were tested against S. aureus and MRSA strains to determine the most active compounds then percent hemolysis confirmed little RBC lysis among the compounds.  Synergistic activity was also tested for HSGN-2241 previously synthesized within the group.  Biofilm eradication assays were completed for HSD 1919 alongside time kill assays.

History

Degree Type

  • Master of Science

Department

  • Chemistry

Campus location

  • West Lafayette

Advisor/Supervisor/Committee Chair

Herman O. Sintim

Additional Committee Member 2

Uma K. Aryal

Additional Committee Member 3

Elizabeth I. Parkinson

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