Purdue University Graduate School
Browse

File(s) under embargo

Reason: Data waiting for publication

1

year(s)

3

month(s)

2

day(s)

until file(s) become available

DISTINCT ROLES OF THE aD HELIX IN aCAMKII ACTIVATION CHARACTERIZED USING A DE NOVO MUTATION FROM CHILDREN WITH LEARNING DISABILITIES

thesis
posted on 2023-08-07, 14:42 authored by Walter SaideWalter Saide

This dissertation describes the effects of a de novo mutation of CaMKII found in children with learning disabilities and describes its effect on catalytic activity. We develop a malachite green assay for the measurement of CaMKII activation and use it for high-throughput chemical screening to identify CaMKII inhibitors and enhancers. We also propose a new mechanism of regulation of CaMKII activity by ADP.


History

Degree Type

  • Doctor of Philosophy

Department

  • Medicinal Chemistry and Molecular Pharmacology

Campus location

  • West Lafayette

Advisor/Supervisor/Committee Chair

Andy Hudmon

Additional Committee Member 2

Carol Post

Additional Committee Member 3

Vincent Jo Davisson

Additional Committee Member 4

Tamara Kinzer-Ursem

Additional Committee Member 5

Darci Trader