Design and Synthesis of Novel Chiral Base

In organic synthesis, controlling stereochemistry can be a challenge whether you are working with small molecules or larger natural products. Current chiral bases, such as Sparteine, are difficult to make or expensive to purchase. Their other drawback is that many chiral bases only can access one stereochemical configuration, not both. In the work presented here, progress has been made towards developing a chiral base from an amino acid derivative, L-valine. The chiral base has been fully synthesized. The use of the amino acid starting material, allows for us to make both the R and S selective amino acid. Efforts are being made to determine the efficacy of the base to control stereochemistry.