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Developmental Toxicity Assessment of Perfluoroalkyl Substances (PFAS) Using Zebrafish Model System

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posted on 2022-07-28, 20:55 authored by Ola WaselOla Wasel

  

Perfluoroalkyl substances (PFAS) are synthetic chemicals that are composed of fluorinated aliphatic chains and are widely used in industrial and consumer products. These chemicals are very stable and persist in the environment. Due to concerns linked with longer chain PFAS, shorter chain chemicals are being used as replacements. There are limited human health data regarding the shorter chain chemicals. In addition, these alternatives are persistent in the environment similar to the longer chain PFAS. The main objective of this dissertation was to assess developmental toxicity of the shorter chain PFAS or shorter chain PFAS with chemical modifications represented by perfluorobutanoic acid (PFBA, C4), perfluorohexanoic acid (PFHxA, C6), perfluorobutane sulfonate (PFBS, C4), and perfluoro-2-proxypropanoic acid (GenX, C6). Overall, the results showed that chain length and functional group are determinants of toxicity of PFAS. All tested PFAS induced one or more developmental adverse outcome, but the effects of each chemical are unique, warranting further studies to address the toxicity of the replacement PFAS. 

Funding

University of Illinois at Chicago—NIOSH Pilot Project Research Training Program (Grant # T42/OH008672)

University of Cincinnati Education and Research Center- NIOSH Pilot Project Research Training Program (Grant #T42OH008432)

Purdue Research Foundation (PRF) research grant

Purdue University office of the vice president for research category 1 grant National Institute of Environmental Health Sciences (Grant # 1R21 ES031646-01A1)

History

Degree Type

  • Doctor of Philosophy

Department

  • Health Science

Campus location

  • West Lafayette

Advisor/Supervisor/Committee Chair

Dr. Jennifer L. Freeman

Additional Committee Member 2

Dr. Aaron Bowman

Additional Committee Member 3

Dr. Linda Lee

Additional Committee Member 4

Dr. Maria S. Sepulveda

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