This dissertation is a collection of four essays on nonstationary time series econometrics, which are grouped into four chapters. The first chapter investigates the inference in mildly explosive autoregressions under unconditional heteroskedasticity. The second chapter develops a new approach to forecasting a highly persistent time series that employs feasible generalized least squares (FGLS) estimation of the deterministic components in conjunction with Mallows model averaging. The third chapter proposes new bootstrap procedures for detecting multiple persistence shifts in a time series driven by nonstationary volatility. The last chapter studies the problem of testing partial parameter stability in cointegrated regression models.