Purdue University Graduate School
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Eduardo Ramirez - Purdue MS Thesis (FINAL).pdf (2.99 MB)

EVALUATION OF AMINOINDOLE CARBOXAMIDES AND TRIAZINES AS POTENTIAL ANTI-AGGREGATION AGENTS OF PROTEIN MISFOLDING DISEASES

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thesis
posted on 2024-05-06, 16:57 authored by Eduardo RamirezEduardo Ramirez

My research projects focuses on the dual targeting of small molecules to abrogate aberrant α-syn, tau (2N4R), and p-tau (1N4R) aggregation and to reduce the spread of AD and related dementias. Not very many drug discovery programs focus on the specific isoforms of the tau protein. We established two series of compounds: aminoindole compounds connected by a carboxamide and triazine compounds connected by a triazine linker. Using biophysical methods we evaluated the effectiveness of both series of compounds in decreasing the amount of misfolded α-syn and tau protein in order to explore their anti-aggregation potential.


Funding

Financial support was provided by the Pharmaceutical Research and Manufacturers of America Foundation (730313), NIH NIA1K08AG071985-01A1, and NIH R21AG070447-01A1.

History

Degree Type

  • Master of Science

Department

  • Basic Medical Sciences

Campus location

  • West Lafayette

Advisor/Supervisor/Committee Chair

Jessica Fortin

Additional Committee Member 2

Marxa Figueiredo

Additional Committee Member 3

Danzhou Yang

Additional Committee Member 4

Jean-Cristophe Rochet