Purdue University Graduate School
Nathan Wilson Thesis.pdf (2.44 MB)

Effects of Formulation and Manufacturing Conditions on Protein Structure and Physical Stability

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posted on 2019-11-06, 21:05 authored by Nathan E WilsonNathan E Wilson
This work focuses on the effects of formulation and manufacturing as it effects protein structure and physical stability. Using common physical characterization techniques, X-ray photoelectron spectroscopy, and solid-state hydrogen/deuterium exchange with mass spectrometry, correlations are identified between these results and accelerated stability studies.


Degree Type

  • Doctor of Philosophy


  • Industrial and Physical Pharmacy

Campus location

  • West Lafayette

Advisor/Supervisor/Committee Chair

Qi Tony Zhou

Advisor/Supervisor/Committee co-chair

Elizabeth M. Topp

Additional Committee Member 2

Lynne S. Taylor

Additional Committee Member 3

Suzanne M. D'Addio