Recent advances in atomically thin two-dimensional materials have led to various promising technologies such as nanoelectronics, sensing, energy storage, and optoelectronics applications. Graphene with sp2-bonded carbon atoms densely packed in a honeycomb crystal lattice has attracted tremendous interest with excellent electrical, optical, mechanical, and chemical properties. In this work, graphene’s mechanical properties, chemical properties, and piezoelectric properties are explored as graphene is implemented in the automotive electrical distribution system. Graphene is useful in friction reduction, corrosion protection, and piezoelectric energy harvesting cell improvement. Besides graphene, transition metal dichalcogenides (TMDs), which are the metal atoms sandwiched between two chalcogen atoms, have also attracted much attention. Unlike graphene, many TMDs are semiconductors in nature and possess enormous potential to be used as a potential channel material in ultra-scaled field-effect transistors (FETs). In this work, chemical doping strategies are explored for the tunnel FETs applications using different metal phthalocyanines and polyethyleneimines as dopants. TMDs FETs can also be used as a selective NO2 gas sensor with a polydimethylsiloxane filter and a highly sensitive photo-interfacial gated photodetector application.