2023.3.8 EXPLORATORY STUDY OF DEEP BRAIN STIMULATION IN THE SYNGAP1+_- MOUSE MODEL OF AUTISM SPECTRUM DISORDER USING ELECTROPHYSIOLOGY.pdf (2.2 MB)
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Exploratory Study of Deep Brain Stimulation in the Syngap1+/-Mouse Model of Autism Spectrum Disorder using Electrophysiology

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posted on 2023-03-08, 16:28 authored by Umm E Hani AbdullahUmm E Hani Abdullah

Syngap1+/ -haploinsufficiency is phenotypically characterized by autism spectrum disorder (ASD), intellectual disability (ID), and epilepsy. SynGAP(Synaptic Ras GTPase-activating protein) is a protein that regulates function in synapses. In addition, SynGAP protein is an integral component of the post-synaptic density and its role in signaling pathway converges with other autism risk genes and consequently autism risk proteins. A critical gap exists to understand how electrical stimulation as part of the Hebbian theory, can induce neuroplasticity. Previously, success in alleviating self-injurious behavior along with facilitating speech formation was demonstrated in adolescent patients undergoing deep brain stimulation (DBS) of the basolateral amygdala (BLA). Therefore, we sought to develop a chronic DBS model in Syngap1+/- haploinsufficient mice that can be used to assess the behavior and proteomic correlates due to DBS in BLA. 

Funding

International Neuromodulation Society Innovative Research Grant

History

Degree Type

Master of Science in Biomedical Engineering

Department

Biomedical Engineering

Campus location

West Lafayette

Advisor/Supervisor/Committee Chair

Tamara Kinzer-Ursem

Additional Committee Member 2

Karin Ejendal

Additional Committee Member 3

Maria Dadarlat Makin