Purdue University Graduate School
wetherill_dissertation_no_endnote_clean_2018_12_06.pdf (1.1 MB)

Externalizing Disorders: Genetics or Prenatal Alcohol Exposure?

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posted on 2019-01-16, 18:25 authored by Leah WetherillLeah Wetherill
Externalizing disorders such as attention deficit hyperactivity disorder (ADHD), conduct disorder (CD), and oppositional defiant disorder (ODD) have a high prevalence rate in both children of alcoholics and in those with prenatal alcohol exposure (PAE). These disorders are also predictors of alcohol dependence (alcdep), heritable, and share an underlying genetic liability with alcdep. Furthermore, a mother who drinks while pregnant is likely to be alcohol dependent (AD), and vice-versa. This study incorporated these factors into one model, including as well as a measure of broad genetic risk for ADHD and alcdep to test for the contributions of these effects simultaneously. An independent sample was used to confirm the results for PAE and broad genetic risk. The hypothesis is that PAE will increase the risk to ADHD but not to CD or ODD.


Defining Translational Approaches for the Image-based Detection of Prenatal Alcohol Exposure

National Institute on Alcohol Abuse and Alcoholism

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Collaborative Study on the Genetics of Alcoholism (COGA)

National Institute on Alcohol Abuse and Alcoholism

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Degree Type

  • Doctor of Philosophy


  • Psychological Sciences

Campus location

  • Indianapolis

Advisor/Supervisor/Committee Chair

Charles Goodlett

Advisor/Supervisor/Committee co-chair

Tatiana Foroud

Additional Committee Member 2

Nicholas Grahame

Additional Committee Member 3

Sarah Mattson

Additional Committee Member 4

Bethany Neal-Beliveau

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