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NEURAL UNDERPINNINGS OF TEMPORAL PROCESSING IN THE AGING AUDITORY SYSTEM

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Neural Underpinnings of Temporal Processing in the Aging Auditory System

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posted on 2024-03-05, 15:03 authored by Varsha Mysore AthreyaVarsha Mysore Athreya

Individuals with typical audiometric sensitivity exhibit varying speech perception abilities in noisy environments, which may decline with age. Temporal processing plays a pivotal role in speech perception, especially in challenging listening conditions. Auditory decline due to aging involves both peripheral pathology and central auditory system changes, impacting temporal processing. To delineate the contributions of these changes, measurements of within- and across-channel temporal processing were conducted in a wide age range of normal-hearing individuals. Robust perception of within-channel temporal cues requires precise coding at both peripheral and central auditory pathway levels, while cross-channel processing relies on central mechanisms. Comprehensive data collection involved behavioral and electrophysiological measures, revealing age-related increases in behavioral thresholds, less robust cortical responses to gaps and temporal-coherence changes, and declining SPIN performance. Cross-channel measures proved to be more predictive of speech perception outcomes, emphasizing the significance of central auditory changes in age-related perceptual deficits.

A mini-EEG cap to record cortical EEG auditory responses to gaps in chinchillas using a new sedation protocol was validated. This advancement enhances translational potential and paves the way for exploring cortical auditory processing using complex stimuli in animal models. By facilitating simultaneous exploration of both subcortical and cortical consequences of auditory system pathologies, this development contributes to a more comprehensive understanding of auditory processes across species.

Funding

Individualized assays of supra-threshold hearing deficits

National Institute on Deafness and Other Communication Disorders

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Effects of Sensorineural Hearing Loss on Robust Speech Coding

National Institute on Deafness and Other Communication Disorders

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History

Degree Type

  • Doctor of Philosophy

Department

  • Health Science

Campus location

  • West Lafayette

Advisor/Supervisor/Committee Chair

Michael G Heinz

Additional Committee Member 2

Hari Bharadwaj

Additional Committee Member 3

Elizabeth Strickland

Additional Committee Member 4

Edward Bartlett