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RADIOLUMINESCENT NANOPARTICLES FOR MULTIMODAL CANCER TREATMENT

thesis
posted on 2022-08-01, 20:24 authored by Kaustabh SarkarKaustabh Sarkar

  

Conventional clinical therapies for head and neck squamous cell carcinomas (HNSCC) include surgical resection, chemotherapy (CT), and radiotherapy (RT). For locally advanced HNSCC, the CT-RT combination (“chemoradiation”) has been shown to be more effective than CT or RT alone and is the current standard of care. A novel radiation-controlled drug release nanoparticle formulation has been developed to realize the maximum benefits of intratumoral CT-RT. Under the application of low-dose X-ray, the formulation is capable of releasing PTX and providing localized, controlled, and sustained drug release for improvements in therapeutic efficacies.

History

Degree Type

  • Doctor of Philosophy

Department

  • Chemical Engineering

Campus location

  • West Lafayette

Advisor/Supervisor/Committee Chair

You-Yeon Won

Additional Committee Member 2

John Morgan

Additional Committee Member 3

Julie Liu

Additional Committee Member 4

Bennett D. Elzey

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