Purdue University Graduate School
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THE DETECTION OF SHORT-LIVED REACTION INTERMEDIATES IN SOLUTION, CHARACTERIZATION OF METAL COMPLEXES, AND THE CONFORMATIONAL CHANGE OF 1-BROMOPROPANE UPON BINDING TO ΑLPHA-CYCLODEXTRIN

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posted on 2022-12-07, 01:59 authored by Victoria BoulosVictoria Boulos

  

The development of a novel technique employing the use of a linear quadrupole ion trap mass spectrometer coupled to a Nd:YAG laser and a home-built fast reagent-mixing apparatus is detailed and used to detect the short-lived tetrahedral reaction intermediate of the reaction of acetyl chloride with ethanol in microdroplets. Additionally, tandem and high-resolution mass spectrometry is used to characterize potential precursors for solution-processed metal selenide semiconductors in order to determine a synthetic route to sulfur-free thin films. Lastly, Raman MCR (multivariate curve resolution) spectroscopy is used to study the binding-induced conformational change of 1-bromopropane upon binding to α-cyclodextrin as a model system to examine guest conformational changes upon binding to a host molecule.

History

Degree Type

  • Doctor of Philosophy

Department

  • Chemistry

Campus location

  • West Lafayette

Advisor/Supervisor/Committee Chair

Hilkka Kenttamaa

Additional Committee Member 2

Adam Wasserman

Additional Committee Member 3

Dor Ben-Amotz

Additional Committee Member 4

Scott A. McLuckey

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