Purdue University Graduate School
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TOWARD ADVANCED NEURAL INTERFACES FOR SELECTIVE VAGUS NERVE STIMULATION.

thesis
posted on 2023-08-08, 17:28 authored by Jongcheon LimJongcheon Lim

In this dissertation, we show three approaches towards selective vagus nerve stimulation (VNS). First, we investigated VNS using microelectrode with circle and Vicsek fractal shape. Our rat study shows that fractal microelectrode can activate C-fibers in cervical vagus nerve with higher energy efficiency compared to circle microelectrode. Secondly, we developed stretchable and adhesive cuff device for a compliant neural interface for a long-term stability. We designed Y-shaped kirigami thin-film device for stretchable neural interface and applied a tissue-adhesive hydrogel to enable tough adhesion of the cuff electrode, which can be potentially used to fix the position of microelectrode for a reliable selective stimulation with minimal mechanical mismatch. Lastly, we developed a microchannel electrode array device to potentially measure high-quality of single fiber action potential (SFAP) from the abdominal vagal trunk of rat to explore natural patterns selective organ activities which can be used for a fine-tuned selective VNS. Our results show the potential of measuring C-fiber activities evoked by cervical VNS.

Funding

OT2 OD028183

ECCS-1944480

History

Degree Type

  • Doctor of Philosophy

Department

  • Biomedical Engineering

Campus location

  • West Lafayette

Advisor/Supervisor/Committee Chair

Hyowon Lee

Advisor/Supervisor/Committee co-chair

Matthew P. Ward

Additional Committee Member 2

Chi Hwan Lee

Additional Committee Member 3

Edward L. Bartlett