The development of child temperament during the first year of life, its relationships to neurodevelopmental risk, and its associated psychobiological predictors was examined. Latent curve growth analysis suggested that the first year of life may have two distinct developmental groups with one group characterized by high levels of surgency and orienting/regulating and with one group characterized primarily by lower levels of these traits. These two developmental trajectory groups were unrelated to ADHD family risk, MDD family risk, and frontal asymmetry; however, the groups were associated with current maternal depression.