SYNTHESIS AND SAR STUDY OF 3H-PYRAZOLO[4,3-f]QUINOLINE BENZAMIDE DERIVATIVES AS POTENTIAL STING MODULATORS

This thesis focuses on the synthesis and evaluation of 3H-pyrazolo[4,3-f]quinoline-containing benzamide derivatives as potential inhibitors of the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway, a crucial mechanism in immune response regulation. While STING activation is vital for defending against pathogens and cellular stress, its dysregulation can lead to autoinflammatory and autoimmune diseases. To address this, the development of small-molecule STING inhibitors has become a key area of therapeutic research. In this study, a novel library of small molecules was synthesized using a Povarov-Doebner type multicomponent reaction (MCR) followed by amidation, with several derivatives exhibiting strong binding affinity towards STING. The results underscore the potential of 3H-pyrazolo[4,3-f]quinoline-based compounds as promising candidates for treating STING-driven inflammatory diseases.