<p dir="ltr">This dissertation investigates how art-based co-creation can improve the quality of life (QoL) in transitional urban–rural interface communities facing spatial fragmentation, cultural erosion, and uneven development. In response to these challenges, I propose the Art-Based Co-Creation Framework (ABCCF), a seven-step participatory process that integrates local engagement, artistic collaboration, and embedded evaluation. The framework is grounded in interdisciplinary literature on co-creation, participatory design, and QoL assessment, and is validated through seven empirical case studies in China and the United States. These include pilot projects and large-scale interventions such as the Golden Years Project, Art for the People, and Exhibit Columbus. Through qualitative methods—participant observation, stakeholder interviews, oral histories, and semantic analysis using ATLAS.ti—the research identifies and tracks three key QoL indicators: social cohesion, cultural identity, and education and skill development. Each case demonstrates how context-sensitive, art-based interventions can activate community agency, bridge generational gaps, and foster emotional well-being while responding to local values. The iterative refinement of the ABCCF through field practice confirms its adaptability and practical value, offering a replicable tool for culturally grounded revitalization and inclusive community governance. This study contributes a structured yet flexible model for scholars and practitioners seeking to integrate artistic practice with sustainable development goals in transitional regions.</p>