Chau Nguyen - Master Thesis.pdf (10.73 MB)

Paper Spray - Mass Spectrometry: Investigation of Sampling Devices for Illicit Drug Detection and Quantification

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thesis
posted on 06.08.2021, 13:21 by Chau Bao NguyenChau Bao Nguyen
Different sampling devices for paper spray - mass spectrometry (PS - MS) were investigated to improve the assay’s simplicity and sensitivity over traditional approaches. In the first one, pressure-sensitive adhesive paper was used as both sampling tool to collect drug residues on surfaces and paper substrate in PS - MS analysis. This method showed a significant improvement in drug collection on surfaces leading to low nano-gram level detection limits. Other sampling device being investigated was snap-in solid-phase extraction column, which demonstrated the ability to detect trace amounts of drugs in plasma while allowed easy transportation and the use of PS - MS automated system.

Funding

U.S. Army Combat Capabilities Development Command Chemical Biological Center (DEVCOM CBC) Explosives Forensics Program

History

Degree Type

Master of Science

Department

Chemistry

Campus location

Indianapolis

Advisor/Supervisor/Committee Chair

Nicholas E. Manicke

Additional Committee Member 2

John V. Goodpaster

Additional Committee Member 3

Frederique T. Deiss